Time to pregnancy (TTP) was much longer in couples in which the men had higher concentrations of acetaminophen in the urine compared to it was among couples in which the men had reduced concentrations of the usually used discomfort reliever, according to a report published online July 13 in Human Reproduction.
Exposure to acetaminophen could come from the environment, too as in the type of a pill. Para-aminophenol is a breakdown product of the 2 acetaminophen and aniline, which is used in the manufacture of certain pesticides, rubber products, dyes, and polyurethane foam, and is present in some cosmetics, food, and clothing. Epidemiological and pet dog studies suggest acetaminophen could be an endocrine disruptor.
Melissa Smarr, a postdoctoral fellow from the Division of Intramural Population Good health Study at the Eunice Kennedy Shriver National Institute of Youngster Good health and Human Progress at the National Institutes of Health, Bethesda, Maryland, and colleagues examined feasible association of urinary acetaminophen concentration in men and TTP among their partners.
The researchers examined acetaminophen and para-aminophenol concentrations in the solitary urine sample provided at the onset of participation in the Longitudinal Investigation of Fertility and the Environment (LIFE) study. This prospective cohort study entails 501 couples living in Michigan or Texas that attempted pregnancy in between 2005 and 2009.
The researchers followed couples for up to a year. Pregnancy taken place for 347 (69%) of the 501 couples throughout the study period. higher concentration of acetaminophen in women was not associated along with much longer TTP, however in men there was a modest association.
Urinary concentration was better for women compared to men (median, 26.6 vs 13.2 ng/mL, respectively; P < .0001). Couples in which the men had concentration of the drug exceeding 73.5 ng/mL were 35% much less most likely to come to be pregnant compared to couples in which the men had much less compared to 5.4 ng/mL acetaminophen. Outcomes were adjusted for age, physique mass index, urinary creatinine, hypothyroidism, hypertension, preconception smoking status, race/ethnicity, and household income.
The analysis used fecundability odds ratios (FORs), in which estimates lesser compared to 1.0 indicate much longer TTP and “diminished fecundity.” The highest quartile of drug concentration for men was associated along with much longer TTP (FOR, 0.67; 95% assurance interval, 0.47 – 0.95), which remained after adjustment for female urinary acetaminophen concentration and male hypothyroidism and hypertension (FOR, 0.65; 95% assurance interval, 0.45 – 0.94).
The couples becoming pregnant had the lowest urinary concentrations of acetaminophen, and those not becoming pregnant had the lowest concentrations of the metabolite.
The researchers desire caution in interpreting the findings, which “await corroboration utilizing Study that incorporates serial collection of urinary [acetaminophen] and detailed post when it come to medicinal and environmental exposures in the context of couple fecundity.”
Limitations of the study contain usage of just one urine measurement and the several-hr half-life of acetaminophen, too as absence of post when it come to indicators for taking acetaminophen.
This Study was supported by the Eunice Kennedy Shriver National Institute of Youngster Good health and Human Development. The researchers have actually disclosed no relevant financial relationships.
Hum Reprod. Published online July 13, 2016. Abstract
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